PharmaGuide Application
(The app contains CEPHALOSPORINS data only by default. Full data is available through annual subscriptions. Users with add-on scratch cards can use the app with full data for one month)
Instant and predictive search by:
Brand
Generic name (eg, cefoperazone)
Contents (eg Cefoperazone and Sulbactam)
Therapeutic category (eg, Cephalosporins)
Interaction Checker:
The interaction checker feature allows you to quickly identify any interactions between prescribed medications.
You can select GENERICS as well as BRANDS in your country to check the interaction.
Risk factors
The information provided under Risk Factors includes contraindications, precautions and risks during pregnancy and breastfeeding for the relevant product.
Pregnancy: the risk cannot be excluded.
Breastfeeding: Contraindicated.
Contraindications: Severe respiratory depression, severe obstructive pulmonary diseases.
Precautions: COPD, intracranial hypertension, impaired consciousness, head trauma, bradyarrhythmia, renal or hepatic insufficiency. Monitor for signs of respiratory depression. Brain tumor. Risk of tolerance and dependence. Elderly or debilitated patients.
Dosage (with indications)
Fast, easy and timely access to precise dosage in specific indications
Usual doses are: Adults: Usually 1 g daily by deep IM injection, slow IV injection over at least 2 to 4 min, or IV infusion. Severe infections, 2 to 4 g as a single dose every 24 hours. Children: Usually 20 to 50 mg/kg once daily by IM injection, slow IV injection over at least 2 to 4 min, or IV infusion. Severe infections, up to a maximum of 80 mg/kg daily. Doses greater than 50 mg/kg should be given by slow IV infusion over at least 30 minutes. Neonates: IM/IV: Postnatal age ≤ 7 days or > 7 days (body weight ≤ 2 kg): 50 mg/kg/day given every 24 hours. Postnatal age > 7 days, body weight > 2 kg: 50 to 75 mg/kg/day administered every 24 h.
Administration
How to prepare and administer, for example, an injectable
The drug may be administered by intermittent intravenous infusion over a period of 10 to 30 minutes; the final concentration for intravenous administration should not exceed 40 mg/ml. The drug has also been administered by direct intravenous infusion over a period of 2 to 4 minutes. Inject deep IM into a large muscle mass.
IM injection: 250 mg/500 mg/1000 mg VIAL: To obtain a concentration of 250 mg/ml, add 0.9 ml of water for injections to a 250 mg vial, 1.8 ml to a 500 mg vial and 3.6 ml to a 1000 mg vial.
IV: 250 mg/500 mg/1000 mg VIAL: To obtain a concentration of 100 mg/ml, add 2.4 ml of water for injections to a 250 mg vial, 4.8 ml to a 500 mg vial and 9.6 ml to a 1000 mg vial.
Compatibility: Stable in D5W, D10W, NS, 5% sodium bicarbonate, bacteriostatic water, SWFI.
Stability: For IV infusion in NS or D5W, the solution is stable for 3 days at room temperature or 10 days in the refrigerator.
Interactions
Amikacin, aminoglycosides, anticoagulants, gentamicin, kanamycin, neomycin, netilmicin, streptomycin, tobramycin, warfarin.
Side effects
Gastrointestinal disorders, skin reactions, blood dyscrasias. Rarely pseudomembranous colitis, increased liver enzymes, glycosuria, oliguria, hematuria, bronchospasm, phlebitis at the injection site, urinary and biliary precipitates, pancreatitis.
Alternative products
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